Driver Projects
PRECISE-SG100K initiated an open Call for Proposals in November 2023 inviting researchers in Singapore to submit proposals that utilise the rich PRECISE-SG100K resource and aim to advance scientific knowledge and enable clinical translation.
As part of the call, 28 Driver Projects were selected based on the scientific value, deliverables, project plan, and project team.
Driver Projects
|
S/N |
Driver Project Title |
Lead PI |
Institution |
|
1 |
Computation of genome-wide LD scores and matrices from the SG100K resource |
Li Jingmei |
A*STAR Genome Institute of Singapore |
|
2 |
Chronic liver disease is a significant risk factor for adverse cardiometabolic outcomes |
Mark Chan |
National University Hospital |
|
3 |
Nonlinear methods for genomic association analysis of eye diseases |
Liu Dianbo |
National University of Singapore |
|
4 |
Advancing the understanding of biological mechanisms influencing chronic inflammatory skin diseases |
Yew Yik Weng |
National Skin Centre |
|
5 |
Mood and diet in patients with irritable bowel syndrome (IBS) in Singapore |
Kuang Ziyang Jonathan |
Tan Tock Seng Hospital |
|
6 |
The contribution of genetics to dietary habit and its relation to adiposity and cardiometabolic diseases in multiethnic Asian population |
Theresia Mina |
Lee Kong Chian School of Medicine |
|
7 |
A structural variation catalogue across three ancestrally diverse Singaporean populations |
Joanna Tan Hui Juan |
A*STAR Genome Institute of Singapore |
|
8 |
Genome-wide association study and population-based evaluation of patients with diabetic foot ulcers |
Joseph Lo |
Woodlands Health |
|
9 |
The SG100K_cancer and aging workgroup: Developing risk models for cancer associations |
Joanne Ngeow |
Lee Kong Chian School of Medicine |
|
10 |
Genetic susceptibility of age-related hearing loss |
Liu Jianjun |
A*STAR Genome Institute of Singapore |
|
11 |
Evaluating the promise and perils of glucagon-like peptide-1 (GLP-1) receptor agonist: a deep dive into therapeutic potentials and adverse effects |
Huang Jian |
A*STAR Singapore Institute for Clinical Sciences |
|
12 |
Unravelling the pathogenesis of inflammatory bowel disease and associated immune-mediated disorders in the Singaporean population |
Sunny Wong |
Lee Kong Chian School of Medicine |
|
13 |
Genetics of allergic diseases and acne vulgaris in the Singapore population: validation and functional characterisation of candidates |
Chew Fook Tim |
National University of Singapore |
|
14 |
Modulation of cholesterol 7α-hydroxylase (CYP7A1) activity as an orthogonal approach to the management of hypercholesterolemia |
Ho Han Kiat |
National University of Singapore |
|
15 |
Multi-omics data analysis for novel depression mechanisms using deep learning tools |
Mu Yuguang |
Nanyang Technological University |
|
16 |
Asian-specific Parkinson’s disease-linked genetic risk variants and systemic clinical outcomes |
Tan Eng King |
National Neuroscience Institute |
|
17 |
Physiological, environmental and genetic determinants of heterogeneity in Singaporeans’ health span |
Neerja Karnani |
A*STAR Bioinformatics Institute |
|
18 |
Portability of catalogued polygenic risk scores across ancestrally diverse Singaporean populations |
Pierre-Alexis Goy |
A*STAR Genome Institute of Singapore |
|
19 |
Advancing Asian-centric liver disease treatment: machine learning applications in MASLD and MetALD precision medicine |
Tan Nguan Soon |
Lee Kong Chian School of Medicine |
|
20 |
Unravelling the correlation between sarcopenia with lifestyle, genetics, and comorbid diseases |
Teh Bin Tean |
National Cancer Centre Singapore |
|
21 |
Young-onset obesity and determinants of cancer prevalence |
Yusuf Ali |
Lee Kong Chian School of Medicine |
|
22 |
Implications of alternative splicing of voltage-gated calcium channels in schizophrenia |
Soong Tuck Wah |
National University of Singapore |
|
23 |
Exploring the impact and origins of somatic mutagenesis in cardiovascular disease |
Tan Kar-Tong |
National University of Singapore |
|
24 |
Alport syndrome in the Singapore population: an under-recognised kidney disease? |
Ng Kar Hui |
National University of Singapore |
|
25 |
Risk prediction for congenital and early-onset hearing loss |
Joshua Tay |
National University of Singapore |
|
26 |
Biological age clocks for multiple organ systems and the lifestyle and genetic risk factors of advanced biological age |
Andrea B. Maier |
National University of Singapore |
|
27 |
Identification of risk factors for gastrointestinal cancers through analysis of genetic and phenotypic data |
Patrick Tan |
Duke-NUS Medical School |
|
28 |
Genomic associations of COVID-19 susceptibility & severity in Singapore |
Kelvin Bryan Tan |
Ministry of Health |