Overview

PRECISE-SG100K Resource:

Collecting, Characterising, and Cataloguing Biological and Molecular Data of 100,000 Singaporeans

Overview of PRECISE-SG100K Resource

The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset of ~100,000 Singaporean residents drawn from four major prospective population health studies in Singapore: [1] HELIOS-NTU, SPHS-NUS, SERI-SEED and NHCS-SingHeart. This extensive resource includes:

Research Phenotype Data

1. Questionnaire Data

Detailed health and lifestyle information, including medical history, medications, behavioural risk factors, mental health, and socio-economic status
Singapore-speciﬁc food frequency data, enabling detailed analysis of dietary patterns and nutrient intake
Cognitive function assessments using validated memory and thinking tests

2. Physical Measurements

Comprehensive anthropometric measurements
Digital blood pressure readings
12-lead ECG for cardiac assessment
Spirometry results
7-day physical activity data using Axivity tri-axial accelerometry

3. Advanced Imaging

DXA scans for bone density and body composition
Carotid ultrasound for cardiovascular assessment
Detailed eye examinations including retinal photography, OCT, tonometry, and refraction
Coronary artery calciﬁcation data (representative subset of 2,000 participants)

Molecular Data

Whole genome sequencing data (short read 30X coverage sequencing) generated with the Genome Institute of Singapore (A*STAR) under Phase II of Singapore’s National Precision Medicine Programme.

*Please note: Data availability may be phased, with some datasets becoming accessible at later stages.

[1] Health for Life in Singapore Study (HELIOS), National Technological University (NTU); Singapore Population Health Studies (SPHS), National University of Singapore (NUS); Singapore Eye Research Institute (SERI) – Singapore Epidemiology of Eye Diseases (SEED); National Heart Centre Singapore (NHCS) – SingHeart